Saturday, July 7, 2007

Origins of Human Nervous System Found in Sea Sponges



Origins of Human Nervous System Found in Sea Sponges
Wednesday, June 06, 2007

By Ker Than

That natural bath sponge you use to scrub-a-dub-dub your body might not have a nervous system, but its cells possess many of the genes needed to make one.

The surprising discovery, detailed in June 6 issue of the open-access journal PLoS ONE, suggests the evolutionary origins of the nervous system are much older than scientists previously thought.

The study found that sponges contain about 25 genes that are very similar to human genes found in the synapses of nerve cells.

• Click here to visit FOXNews.com's Evolution & Paleontology Center.

Synapses are bulb-like connections neurons use to communicate; in humans and many other animals, they play a crucial role in learning and memory.

Genes are specific DNA sequences that carry instructions for when, where and how much a certain protein a cell should make.

Synapse-like interactions

"Sponges are the first animals to branch off compared to the rest of animals. They don't have nervous systems, yet we found they have many of the genes that are used in the synapse of modern humans," said Todd Oakley, an evolutionary biologist at the University of California, Santa Barbara (UCSB), who was involved in the study.

Even more surprisingly, the proteins made by the sponge genes were found to interact with one another in ways similar to proteins in human synapses.

"Not only do they have [human synapse genes], they also have this signature that they may be functioning in a similar way in the absence of a nervous system, as they do in the presence of one," Oakley told LiveScience.

The function of the sponge genes are not clear, but their human counterparts combine to form complex protein "machines" important for synaptic communication, Oakley said.

The team's research was made possible by the recent sequencing of the sponge genome, which has yet to be published but is available online.

In addition to lacking nervous systems, sponges also don't have internal organs or muscles.

Sponges are filter-feeders: They spend most of their lives anchored to sediment or rock. Feeding and the excreting wastes are done with the aid of flowing water.

May I borrow that gene?

Scientists think the first true neurons and synapses first appeared on Earth more than 600 million years ago in organisms called cnidarians, which today include the hydra, sea anemone and jellyfish.

"While sponges do show evidence that their cells can communicate with each other, the nervous system is much more efficient," Oakley said.

The researchers speculate that the sponge genes were recycled over evolutionary time, with small modifications, to create the nervous systems of later animals.

"Evolution can take these ‘off-the-shelf' components and put them together in new and interesting ways," said study leader Kenneth Kosik, a UCSB neuroscientist.

Other genes would also have had to evolve or to have been co-opted to create complex nervous systems, such as our own.

Scientists think an estimated 77 to 1,000 genes are important for human synaptic communication, Oakley said.

Copyright © 2007 Imaginova Corp. All Rights Reserved. This material may not be published, broadcast, rewritten or redistributed.




Simple Sea Sponge Helps Scientists Understand Tissue Rejection

Science Daily — Understanding why some transplant patients reject their neworgans requires a working knowledge of how cells recognize and acceptor reject each other. Xavier Fernàndez-Busquets, an MBL researchervisiting from the University of Barcelona, has found the perfect allyin this quest: the red beard sea sponge, an Atlantic species that growsabundantly from just north of Cape Cod down to Florida.


The red beard sponge. (Image courtesy of Marine Biological Laboratory) The redbeard sponge (Microciona prolifera) has a cell-to-cell recognitionsystem that, on a basic level, is similar to that of humans but muchsimpler. It's also a good organism for laboratory research, since itscells and cell adhesion molecules can be isolated with simple, fast,and non-disruptive methods and studied, and because its fingerlikestructures make grafting experiments relatively straightforward.

Inexperiments carried out on these sponges this summer, Dr.Fernàndez-Busquets and his colleagues are studying the cells andmolecules believed to be involved in the process of tissue rejection.By grafting together pieces of different individual sponges that willreject each othera process that approximates what sometimes happens inhuman transplantsthe scientists have observed that cells known as graycells migrate to and amass at the graft site, a clear suggestion thatthey are involved in non-self tissue recognition and rejection.Researchers believe that gray cells may be a primitive form of ourimmune system's human killer cells.

Fernàndez-Busquets has alsobeen researching the role of the molecule called aggregation factorproteoglycan, which he has recently identified as another potentialplayer in sponge tissue rejection reactions, and which is very easy tostudy in sponges. The human version of this molecule, which isdifferent from the sponge version but similar in structure, is alsobelieved to have important functions in cell-to-cell interactions, butis hard to study.

The ultimate goal of this research is toprovide insights into the machinery behind human tissue rejection andimmune responses in hopes of someday being able to control theseprocesses and save lives.

Note: This story has been adapted from a news release issued by Marine Biological Laboratory.


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4 comments:

jaga said...

We thought you might be interested --


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